Protein Modification Reagents
ABclonal Technology NRIP2 Rabbit pAb
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in cytoplasm.
Medchemexpress LLC Bis-Mal-Lysine-PEG4-TFP ester | 1426164-53-5 | 98.0% | C37H45F4N5O13 | 100 MG
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker utilized in PROTAC synthesis. PROTACs feature two distinct ligands joined by a linker: one targeting an E3 ubiquitin ligase, the other the protein of interest. This mechanism enables PROTACs to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Enables selective degradation of target proteins
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.17% | C47H61N5O9S | 100 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have azide groups
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
PEPTIDE SOLUTIONS LLC Biotin-PEG(4)-SS-Tyramide | 50mg
Biotin-PEG(4)-SS-Tyramide | MW: 774.02 | 50mg
Worthington Biochemical Corporation TRPYSIN TPCK TREATED
Chromatographically purified trypsin treated with L-(tosylamido-2-phenyl) ethyl chloromethyl ketone (TPCK) to inhibit contaminating chymotryptic activity according to Kostka, V., and Carpenter, F.H.: JBC, 239, 1799 (1964).
Medchemexpress LLC Endo-BCN-PEG4-PFP ester | 2904607-26-5 | 95.0% | 607.56 | 25 MG
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It acts as a click chemistry reagent, featuring a BCN group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This mechanism supports the development of PROTACs, which degrade target proteins via the ubiquitin-proteasome system. This product is for research use only.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a BCN group for SPAAC with azide groups
- Used in PROTAC synthesis
- Enables selective degradation of target proteins
- Functions through the intracellular ubiquitin-proteasome system
- Intended for research use only
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 100 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules composed of two distinct ligands connected by a linker. These molecules harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used as a PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Selectively degrades target proteins via the ubiquitin-proteasome system
Medchemexpress LLC endo-BCN-PEG2-C2-NHS ester | 2243565-12-8 | 95.0% | 450.48 | 250 MG
endo-BCN-PEG2-C2-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs consist of two different ligands connected by a linker, enabling the exploitation of the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
STA PHARMACEUTICAL US LLC Fmoc-amino-PEG3-CH2COOH | 5 g | CAS 139338-72-0 | MDL MFCD13182400
Fmoc-amino-PEG3-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 139338-72-0
- MDL: MFCD13182400
- InChIKey: XNOJSAOJCBOZTA-UHFFFAOYSA-N
- Molecular Weight: 429.469
- Molecular Formula: C23H27NO7
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
- SMILES: O=C(COCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC DSPE-PEG-Amine, MW 5000 | 95.0% | 100 MG
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound is intended for research use only. PROTACs function by connecting two ligands, one for an E3 ubiquitin ligase and another for a target protein, to exploit the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Designed for selective degradation of target proteins
- Average molecular weight of 5000
- Appears as a solid, white to off-white material
Medchemexpress LLC M-PEG-mal (MW 2000) | 97.27% | 100 MG
M-PEG-mal (MW 2000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are innovative molecules that harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins, utilizing two different ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other for the protein of interest.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Pomalidomide-PEG2-azide | 2267306-14-7 | 96.6% | 444.40 | 25 MG
This product is an E3 ligase ligand-linker conjugate incorporating a cereblon ligand and a 2-unit PEG linker. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition reactions with molecules containing DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate.
- Includes a cereblon ligand.
- Features a 2-unit PEG linker.
- Functions as a click chemistry reagent.
- Contains an Azide group.
- Facilitates copper-catalyzed azide-alkyne cycloaddition.
- Supports strain-promoted alkyne-azide cycloaddition.